Likewise, the next variable is what proportion of the eggs you do retrieve, are good. Typically, younger women have a higher proportion of good eggs, as evidenced by the chart below. Embryo quality is a stand-in for egg quality, and clearly the ratio of good eggs decreases with age. When we add the effects of egg quality and volume together, younger patients clearly have far higher success rates with egg freezing.
Older women need to collect far more eggs to feel confident in a successful outcome. A recent study out of Europe looking at women who electively froze their eggs and returned to use them, gives us a glimpse into the impact of age and egg volume. Right off the bat, you can see that being younger and storing more eggs was a major determinant of success.
Women under 35 with the same number of eggs had twice that success rate. The reality is, these buckets are broad a year-old and year-old aren't equally fertile , the sample size could be bigger, and there could be other variables at work. This is probably directionally accurate, but not worth carving in stone. The dataset was not based on egg freezers, but similar sets of women who'd been treated at a Brigham for non-ovarian reserve related issues e. That lack of confidence affects some patients.
Our data shows patients will often do a second cycle, or even a third, to help drive up the theoretical probability of a live birth. As you can see in the case of women over 36, those extra cycles, and extra eggs, may or may not change the odds — there are certainly diminishing returns to continued cycles.
But the incremental costs are undeniable. Cryopreservation is freezing tissue or cells in order to preserve it for the future. The graph below shows the percentage of IVF egg retrievals in our program that had leftover embryos frozen in Note the significant decrease with advancing female age Percent of IVF egg retrievals with embryos frozen by female age How many embryos are frozen on the average with an IVF cycle?
To embryologists, vitrification is ultra-rapid IVF embryo freezing instead of the traditional slow freezing process To a science dictionary, vitrification is the process of converting something into a glass-like solid that is free of any crystal formation For example, by adding a cryoprotectant, water can be cooled until it hardens like glass without any ice crystals forming.
The first reported pregnancy in humans from frozen embryos was in This may now also be true for human embryos Research continues in this area and human embryo freezing and thawing protocols have improved tremendously over the past 25 years In some clinics including ours , the newer vitrification technique is showing success rates for blastocyst embryos transferred after freezing and thawing that are equivalent to fresh blastocyst transfer success rates Techniques for freezing eggs, sperm and embryos Cryoprotectants are used in the solution that the embryos are frozen in.
Cryoprotectants are useful because they: Lower the freezing point and may prevent intracellular ice formation. May protect cells by interacting with membranes as they change from a pliable to a rigid state. We use the vitrification technique for embryo freezing see above. Our IVF pricing page lists our current charges for storage of frozen embryos and also costs for a frozen embryo transfer cycle. Freezing Embryos Any excess healthy embryos from the IVF process can be frozen, in case more than one treatment cycle is needed.
The advantages of freezing embryos Embryo freezing provides more opportunities for a pregnancy for each hormone stimulation cycle and egg collection. How does embryo freezing work? Success rates with frozen embryos At Hunter IVF, many of our births, over many years, have come from the transfer of frozen and thawed embryos.
Find out more about our fertility preservation program Contact us for more information about freezing embryo and embryo transfer. Request an appointment. Contact us today Call us on Email us about Freezing Embryos. An FET cycle uses minimal or no medication so one embryo can be replaced into a much more natural environment resulting in potentially higher success rate and hopefully a safer pregnancy.
There has been a lot of research on this topic but at present there is still no consensus as to the best policy with different clinics favouring fresh or frozen embryos. Most definitely. The latest success rates from the LWC Cardiff laboratory show that we have achieved great success with our FET programme over the last 15 months. This success has been due to the Precision Embryology we have incorporated into the laboratory. Pictures are taken of the embryos every 5 minutes without disturbing their environment, so we can easily track their development.
We can then freeze or transfer the embryo at exactly the right time. Based on the precision embryology principals, the Cardiff laboratory have achieved very high standards.
This means patients treated at LWC Wales will achieve a high cumulative pregnancy rate by using their fresh and frozen embryos from one egg collection. Patients should be aware that there is a very small chance the embryos will not survive the freezing and thaw process.
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